Recent Advances in the Chemistry of 1,2,4-Oxadiazoles

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Abstract

1,2,4-Oxadiazoles experienced an almost 80-year long period of scientific lethargybefore they tickled the curiosity of chemists. The study of chemical and photochemicalreactivity of 1,2,4-oxadiazoles opened the way to a series of applications in heterocyclicsynthesis. Today, 1,2,4-oxadiazoles are known in medicinal chemistry fortheir use as bioisosters of esters and amides. Furthermore, fluorinated 1,2,4-oxadiazoleshave been applied in materials science either by themselves or for the targetedmodification of polymers and macromolecules. Overall, the synthesis of1,2,4-oxadiazoles can be planned to fine-tune their properties for featured applications.Their versatility, either as starting synthons or as target compounds, hasboosted the number of studies involving 1,2,4-oxadiazoles in the last decade. Thisreview presents a selection of 1,2,4-oxadiazoles applications in materials scienceand medicinal chemistry.
Original languageEnglish
Title of host publicationAdvances in Heterocyclic Chemistry
Number of pages50
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Polymers and Plastics

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