Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice

Daniele La Barbera, Panariello, De Fazio, Aguglia, De Giorgi, Ferri, Giustra, Pigato, Massimo Clerici, Ballerini, Callista, Ferri, Montagnani, Gargiulo, Vernacotola, Tortorella, Panariello, Corrivetti, Mencacci, FavarettoFagiolini, De Filippis, Bernardo Carpiniello, Vita, Maina

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Abstract

Objectives: To identify the variables that are associated with persistence to Aripiprazole-Long Acting (A-LAI), in adult patients with schizophrenia. Methods: Observational, retrospective, non-interventional study involving 261 patients with schizophrenia. Results: Eighty-six percent of study subjects were persistent for at least 6 months. All subjects with baseline CGI-S of 1 or 2, 95% of subjects with CGI-S of 3, 86% with CGI-S of 4, 82% of subjects with CGI-S of 5, 73% of subjects with CGI of 6 and 90% of subjects with CGI of 7 were persistent. A-LAI treatment continuation rate was higher in patients with: 1) baseline CGI score ≤ 4; 2) schizophrenia dimension (LDPS) mania score ≤ 5; 3) psychotic spectrum schizoid score ≤ 11. Conclusions: A relatively high number of patients (n = 225, 86%) were persistent to A-LAI for at least 6 months. Not surprisingly, very severe patients were more unlikely to be persistent. However, it is noteworthy that a large number of subjects with high CGI score at the time when A-LAI was started (82% of subjects with CGI-S of 5, 73% of subjects with CGI of 6 and 90% of subjects with CGI of 7) were persistent. Larger, controlled, prospective and longer studies are warranted.
Original languageEnglish
Pages (from-to)698-706
Number of pages9
JournalPsychiatry Research
Volume272
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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    La Barbera, D., Panariello, De Fazio, Aguglia, De Giorgi, Ferri, Giustra, Pigato, Clerici, M., Ballerini, Callista, Ferri, Montagnani, Gargiulo, Vernacotola, Tortorella, Panariello, Corrivetti, Mencacci, ... Maina (2019). Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice. Psychiatry Research, 272, 698-706.