Rat CNS neurons are not yet programmed to shorten their chromatin repeat length at the end of fetal neurogenesis

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Abstract

Neurons from rat fetal cerebral hemispheres were grown in a synthetic medium (Maat medium), as previously described, for different periods of time. The repeat length of their chromatin was determined by micrococcal nuclease digestion and compared with that of neurons isolated from postnatal rat brain of corresponding ages. In contrast to the in vivo situation, we found that neurons, dissociated at the 16th gestational day and cultured in vitro, did not undergo the shortening of their chromatin repeat, thus indicating that, at the end of their mitotic cycles, they are not yet programmed to this event. © 1986.
Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalCell Biology International Reports
Volume10
Publication statusPublished - 1986

All Science Journal Classification (ASJC) codes

  • Cell Biology

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