Raman Spectroscopic Measurements ofDermal Carotenoids in Breast Cancer Operated Patients ProvideEvidence for the Positive Impact of a Dietary Regimen Rich inFruit and Vegetables on Body Oxidative Stress and BCPrognostic Anthropometric Parameters: A Five-Year Study

Carla Gentile, Luisa Tesoriere, Maria Antonia Livrea, Anna Maria Pintaudi, Anna Perrone, Giuseppe Carruba, Traina, Alessandro Attanzio, Giuseppe Carruba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dermal carotenoids are a feasible marker of the body antioxidative network and may reveal a moderate to severe imbalance of theredox status, thereby providing indication of individual oxidative stress. In this work noninvasive Resonance Raman Spectroscopy(RRS) measurements of skin carotenoids (skin carotenoid score (SCS)) were used to provide indications of individual oxidativestress, each year for five years, in 71 breast cancer (BC) patients at high risk of recurrence. Patients’ SCS has been correlated withparameters relevant to BC risk, waist circumference (WC), and body mass index (BMI), in the aim of monitoring the effect ofa dietary regimen intended to positively affect BC risk factors. The RRS methodological approach in BC patients appeared frompositive correlation between patients’ SCS and blood level of lycopene. The level of skin carotenoids was inversely correlated withthe patients’ WC and BMI. At the end of the 5 y observation BC patients exhibited a significant reduction of WC and BMI andincrease of SCS, when strictly adhering to the dietary regimen. In conclusion, noninvasive measurements of skin carotenoids can(i) reveal an oxidative stress condition correlated with parameters of BC risk and (ii) monitor dietary-related variations in BCpatients.
Original languageEnglish
Number of pages8
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology

Fingerprint Dive into the research topics of 'Raman Spectroscopic Measurements ofDermal Carotenoids in Breast Cancer Operated Patients ProvideEvidence for the Positive Impact of a Dietary Regimen Rich inFruit and Vegetables on Body Oxidative Stress and BCPrognostic Anthropometric Parameters: A Five-Year Study'. Together they form a unique fingerprint.

  • Cite this