Quantitative immunomorphological analysis of heat shock proteins in thyroid follicular adenoma and carcinoma tissues reveals their potential for differential diagnosis and points to a role in carcinogenesis

Daniela Cabibi, Fabio Bucchieri, Alberto Giuseppe Fucarino, Calogero Cipolla, Alessandro Pitruzzella, Sabrina David, Alessandra Maria Vitale, Francesca Rappa, Giuseppa Graceffa, Francesco Cappello, Letizia Paladino, Everly Conway De Macario, Francesco Cappello, Everly Conway De Macario, Alberto J.L. Macario, Stefania Martorana

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Hsp27, Hsp60, Hsp70, and Hsp90 are chaperones that play a crucial role in cellularhomeostasis and differentiation, but they may be implicated in carcinogenesis. Follicular neoplasmsof the thyroid include follicular adenoma and follicular carcinoma. The former is a very frequent benignencapsulated nodule, whereas the other is a nodule that infiltrates the capsule, blood vessels and theadjacent parenchyma, with a tendency to metastasize. The main objective was to assess the potentialof the Hsps in differential diagnosis and carcinogenesis. We quantified by immunohistochemistryHsp27, Hsp60, Hsp70, and Hsp90 on thin sections of human thyroid tissue with follicular adenoma orfollicular carcinoma, comparing the tumor with the adjacent peritumoral tissue. Hsp60, Hsp70, andHsp90 were increased in follicular carcinoma compared to follicular adenoma, while Hsp27 showedno difference. Histochemical quantification of Hsp60, Hsp70, and Hsp90 allows diagnostic distinctionbetween follicular adenoma and carcinoma, and between tumor and adjacent non-tumoral tissue.The quantitative variations of these chaperones in follicular carcinoma suggest their involvement intumorigenesis, for instance in processes such as invasion of thyroid parenchyma and metastasization.
Original languageEnglish
Pages (from-to)4324-
Number of pages11
JournalAPPLIED SCIENCES
Volume9
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Instrumentation
  • General Engineering
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Fingerprint

Dive into the research topics of 'Quantitative immunomorphological analysis of heat shock proteins in thyroid follicular adenoma and carcinoma tissues reveals their potential for differential diagnosis and points to a role in carcinogenesis'. Together they form a unique fingerprint.

Cite this