Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

Arturo Silvestri; Anna Maria Almerico; Antonino Lauria; Giampaolo Barone; Chiara Patella; Ilenia Abbate; Noemi Gambino

Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

Arturo Silvestri, Anna Maria Almerico, Antonino Lauria, Giampaolo Barone, Chiara Patella, Ilenia Abbate, Noemi Gambino

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

Original language	English
Pages (from-to)	5125-5128
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

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title = "Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement",

abstract = "Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.",

author = "Arturo Silvestri and Almerico, {Anna Maria} and Antonino Lauria and Giampaolo Barone and Chiara Patella and Ilenia Abbate and Noemi Gambino",

year = "2008",

language = "English",

volume = "49",

pages = "5125--5128",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

AU - Silvestri, Arturo

AU - Almerico, Anna Maria

AU - Lauria, Antonino

AU - Barone, Giampaolo

AU - Patella, Chiara

AU - Abbate, Ilenia

AU - Gambino, Noemi

PY - 2008

Y1 - 2008

N2 - Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

AB - Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

UR - http://hdl.handle.net/10447/43922

M3 - Article

SN - 0040-4039

VL - 49

SP - 5125

EP - 5128

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

Abstract

All Science Journal Classification (ASJC) codes

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