Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

Arturo Silvestri, Anna Maria Almerico, Antonino Lauria, Giampaolo Barone, Chiara Patella, Ilenia Abbate, Noemi Gambino

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
Original languageEnglish
Pages (from-to)5125-5128
Number of pages4
JournalTetrahedron Letters
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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