Probing in cell protein structural changes with time-resolved X-ray scattering

Giorgio Schiro', Antonio Cupane, Matteo Levantino, Michael Wulff, Marco Cammarata, Alessandro Spilotros

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Investigating protein structural changes inside the cell is a major goal in molecular biology. Here we show that time-resolved wide-angle X-ray scattering is a valuable tool for this purpose. Hemoglobin has been chosen as a model system and its tertiary and quaternary conformational changes following laser flash-photolysis have been tracked in intact red blood cells with nanosecond time resolution.
Original languageEnglish
Pages (from-to)6434-6437
Number of pages4
JournalSoft Matter
Volume8
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

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