Primitive Neuroectodermal Tumor (PNET) of the kidney: a case report

Francesca Rappa, Francesco Cappello, Pierantonio Mancini, Maria G. Cuttanno, Giorgio Pomara, Maria G. Cuttanno, Cesare Selli, Girolamo Morelli, Pierantonio Mancini

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44 Citations (Scopus)


BACKGROUND:A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviour. In our case, a radical nephrectomy with lymphadenectomy was performed and there was no residual or recurrent tumour at 24-month follow-up.METHODS:The surgical specimens were formalin-fixed and paraffin embedded. The sections were stained with routinary H&E. Immunohistochemistry was performed.RESULTS:The immunohistochemical evaluation revealed a diffuse CD99 positivity in the cytoplasm of the neoplastic cells. Pankeratin, cytokeratin AE1/AE3, vimentin, desmin, S100, cromogranin were negative. The clinical presentation and the macroscopic aspect, together with the histological pattern, the cytological characteristic and the cellular immunophenotype addressed the diagnosis towards primary PNET of kidney.CONCLUSIONS:Since sometimes it is difficult to discriminate between PNET and Ewing's tumour, we reviewed the difficulties in differential diagnosis. These tumors have a common precursor but the stage of differentiation in which it is blocked is probably different. This could also explain their different biological behaviour and prognosis.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBMC Cancer
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research


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