Mutations of the ANGPTL3 gene have been associated with a novel form of primary hypobetalipoproteinemia, the combined hypolipidemia (cHLP), characterized by low total cholesterol and low HDL-cholesterol levels. The aim of this work is to define the role of ANGPTL3 gene as determinant of the combined hypolipidemia phenotype in 2 large cohorts of 913 among American and Italian subjects with primary hypobetalipoproteinemia (total cholesterol<5th percentile).
|Number of pages||5|
|Journal||Arteriosclerosis, Thrombosis, and Vascular Biology|
|Publication status||Published - 2012|
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine