Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia

Rosaria Vincenza Giglio, Marcello Ciaccio, Luisa Agnello, Giulia Bivona, Alessandro Iacona, Elisa Parisi, Giuseppe Dejan Lucido

Research output: Contribution to journalArticlepeer-review


Objective: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy.Methods: We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2).Results: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity.Conclusion: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children.
Original languageEnglish
Number of pages7
JournalLaboratory Medicine
Publication statusPublished - 2020

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