Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia

Rosaria Vincenza Giglio, Luisa Agnello, Giulia Bivona, Marcello Ciaccio, Marcello Ciaccio, Rosaria Vincenza Giglio, Elisa Parisi, Alessandro Iacona, Giuseppe Dejan Lucido, Ottavio Ziino, Ottavio Ziino, Alessandro Iacona, Elisa Parisi, Giuseppe Dejan Lucido

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5 Citations (Scopus)

Abstract

Objective: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy.Methods: We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2).Results: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity.Conclusion: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children.
Original languageEnglish
Number of pages7
JournalLaboratory Medicine
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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