Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy

Cesare Gagliardo, Marco D'Amelio, Massimo Midiri, Giorgio Collura, Roberto Cannella, Tommaso Vincenzo Bartolotta, Domenico Iacopino, Patrizia Toia, Maurizio Marrale, Alessandro Napoli, Carlo Catalano, Antonia Pignolo, Giuseppe Filorizzo, Rosario Maugeri

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating.
Original languageEnglish
Pages (from-to)2524-
Number of pages11
JournalScientific Reports
Volume11
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • General

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