Nucleotide changes within an exon may alter the trinucleotide normally encoding a particular amino acid, such that a new stop signal istranscribed into the mRNA open reading frame. A recent approach to directly overcome the deleterious effects caused by nonsense mutations is represented by readthrough strategies which take advantage of the known properties of aminoglycosides that can suppress stop codons.
|Number of pages||2|
|Journal||JOURNAL OF BIOLOGICAL RESEARCH|
|Publication status||Published - 2015|
All Science Journal Classification (ASJC) codes
- General Biochemistry,Genetics and Molecular Biology
- Plant Science
- Biochemistry, medical