PRELIMINARY MAGNETIC RESONANCE RELAXOMETRIC ANALYSIS OF FRICKE GEL DOSIMETERS PRODUCED WITH POLYVINYLALCOHOL AND GLUTARALDEHYDE

Salvatore Gallo, Anna Longo, Giorgio Collura, Antonio Bartolotta, Maurizio Marrale, Luigi Tranchina, Maurizio Marrale, Anna Longo, Giorgio Collura, Salvatore Gallo, Francesco D’Errico, Giuseppina Iacoviello

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Abstract

This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use of a matrix of Poly-vinyl alcohol cross-linked by adding Glutaraldehyde and analyzed by means of nuclear magnetic resonance relaxometry. In previous optical studies, these gels have shown promising dosimetric features in terms of photon sensitivity and low-diffusion of ferric ions produced after irradiation.In this work, we used a portable nuclear magnetic resonance relaxometer to measure the relaxation times (which are important for dosimetric applications) of these gel materials. At this aim, we performed a study for optimizing the acquisition parameters with nuclear magnetic resonance relaxometer. Gel samples were exposed to clinical 6 MV photons in the dose range between 0 and 20 Gy. Nuclear magnetic resonance relaxometry measurements were performed and the sensitivity to photon beams was measured for various values of the Fe2+ ion concentration. The analyses pointed out that the MR signal increases as the Fe2+ content increases and the increase is about 75% when the concentration of Fe2+ ions is increased from 0.5 mM to 2.5 mM. Furthermore, the sensitivity improvement achieved with increasing the Fe2+ concentration is about 60%. This paper shows that portable nuclear magnetic resonance relaxometer used for analysis of porous materials can be used for characterization of these dosimetric gels and this study can be considered as the first step for the characterization of these dosimeters which in the future could be used for 3D dose mapping in clinical applications.
Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalNUCLEAR TECHNOLOGY & RADIATION PROTECTION
Publication statusPublished - 2017

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Dosimeters
Magnetic resonance
Gels
Nuclear magnetic resonance
Photons
Ions
Magnetic resonance measurement
Relaxation time
Porous materials
Alcohols
Irradiation

All Science Journal Classification (ASJC) codes

  • Nuclear Energy and Engineering
  • Safety, Risk, Reliability and Quality

Cite this

PRELIMINARY MAGNETIC RESONANCE RELAXOMETRIC ANALYSIS OF FRICKE GEL DOSIMETERS PRODUCED WITH POLYVINYLALCOHOL AND GLUTARALDEHYDE. / Gallo, Salvatore; Longo, Anna; Collura, Giorgio; Bartolotta, Antonio; Marrale, Maurizio; Tranchina, Luigi; Marrale, Maurizio; Longo, Anna; Collura, Giorgio; Gallo, Salvatore; D’Errico, Francesco; Iacoviello, Giuseppina.

In: NUCLEAR TECHNOLOGY & RADIATION PROTECTION, 2017, p. 242-249.

Research output: Contribution to journalArticle

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abstract = "This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use of a matrix of Poly-vinyl alcohol cross-linked by adding Glutaraldehyde and analyzed by means of nuclear magnetic resonance relaxometry. In previous optical studies, these gels have shown promising dosimetric features in terms of photon sensitivity and low-diffusion of ferric ions produced after irradiation.In this work, we used a portable nuclear magnetic resonance relaxometer to measure the relaxation times (which are important for dosimetric applications) of these gel materials. At this aim, we performed a study for optimizing the acquisition parameters with nuclear magnetic resonance relaxometer. Gel samples were exposed to clinical 6 MV photons in the dose range between 0 and 20 Gy. Nuclear magnetic resonance relaxometry measurements were performed and the sensitivity to photon beams was measured for various values of the Fe2+ ion concentration. The analyses pointed out that the MR signal increases as the Fe2+ content increases and the increase is about 75{\%} when the concentration of Fe2+ ions is increased from 0.5 mM to 2.5 mM. Furthermore, the sensitivity improvement achieved with increasing the Fe2+ concentration is about 60{\%}. This paper shows that portable nuclear magnetic resonance relaxometer used for analysis of porous materials can be used for characterization of these dosimetric gels and this study can be considered as the first step for the characterization of these dosimeters which in the future could be used for 3D dose mapping in clinical applications.",
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AU - Gallo, Salvatore

AU - Longo, Anna

AU - Collura, Giorgio

AU - Bartolotta, Antonio

AU - Marrale, Maurizio

AU - Tranchina, Luigi

AU - Marrale, Maurizio

AU - Longo, Anna

AU - Collura, Giorgio

AU - Gallo, Salvatore

AU - D’Errico, Francesco

AU - Iacoviello, Giuseppina

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N2 - This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use of a matrix of Poly-vinyl alcohol cross-linked by adding Glutaraldehyde and analyzed by means of nuclear magnetic resonance relaxometry. In previous optical studies, these gels have shown promising dosimetric features in terms of photon sensitivity and low-diffusion of ferric ions produced after irradiation.In this work, we used a portable nuclear magnetic resonance relaxometer to measure the relaxation times (which are important for dosimetric applications) of these gel materials. At this aim, we performed a study for optimizing the acquisition parameters with nuclear magnetic resonance relaxometer. Gel samples were exposed to clinical 6 MV photons in the dose range between 0 and 20 Gy. Nuclear magnetic resonance relaxometry measurements were performed and the sensitivity to photon beams was measured for various values of the Fe2+ ion concentration. The analyses pointed out that the MR signal increases as the Fe2+ content increases and the increase is about 75% when the concentration of Fe2+ ions is increased from 0.5 mM to 2.5 mM. Furthermore, the sensitivity improvement achieved with increasing the Fe2+ concentration is about 60%. This paper shows that portable nuclear magnetic resonance relaxometer used for analysis of porous materials can be used for characterization of these dosimetric gels and this study can be considered as the first step for the characterization of these dosimeters which in the future could be used for 3D dose mapping in clinical applications.

AB - This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use of a matrix of Poly-vinyl alcohol cross-linked by adding Glutaraldehyde and analyzed by means of nuclear magnetic resonance relaxometry. In previous optical studies, these gels have shown promising dosimetric features in terms of photon sensitivity and low-diffusion of ferric ions produced after irradiation.In this work, we used a portable nuclear magnetic resonance relaxometer to measure the relaxation times (which are important for dosimetric applications) of these gel materials. At this aim, we performed a study for optimizing the acquisition parameters with nuclear magnetic resonance relaxometer. Gel samples were exposed to clinical 6 MV photons in the dose range between 0 and 20 Gy. Nuclear magnetic resonance relaxometry measurements were performed and the sensitivity to photon beams was measured for various values of the Fe2+ ion concentration. The analyses pointed out that the MR signal increases as the Fe2+ content increases and the increase is about 75% when the concentration of Fe2+ ions is increased from 0.5 mM to 2.5 mM. Furthermore, the sensitivity improvement achieved with increasing the Fe2+ concentration is about 60%. This paper shows that portable nuclear magnetic resonance relaxometer used for analysis of porous materials can be used for characterization of these dosimetric gels and this study can be considered as the first step for the characterization of these dosimeters which in the future could be used for 3D dose mapping in clinical applications.

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