POTENTIAL BENEFITS OF COLOSTRUM IN GASTROINTESTINAL DISEASES

Giovanni Tomasello, Laura Menchetti, Patrizia Casagrande-Proietti, Leonardo Leonardi, Giovanni Tomasello, Patrizia Casagrande-Proietti, Giovanna Traina

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

This paper reviews the composition of colostrum and the potebntial preventive and therapeutic use of this "first milk" for treating various gastrointestinal disorders in humans. Colostrum is a complex biological liquid that is rich in antimicrobial peptides, immune-regulanting compounds and growth factors than the subsequent mature milk. The main functions of colostrum are to provide essential nutritional components, strenghten the natural defense system, modulate immune response, balance intestinal microbiota and enhance the growth and repair of several tissues. several studies and clinical trials carried out both in vitro and in vivo on humans and animals suggest the clinical benefits of bovine colostrum (BC) supplementation in gastro-intestinal diseases. Despite the encouraging results, there are no contraindications regarding high dose levels and few side effects of clinical relevance have been reported. In conclusion, in the near future, colostrum-based supplementations may be play a role to synthetic drugs in the prevention and treatment of various gastrointestinal disorders.
Original languageEnglish
Pages (from-to)331-351
Number of pages21
JournalFRONTIERS IN BIOSCIENCE
Volume8
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology

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