Portraying infective endocarditis: results of multinational ID-IRI study

Antonio Cascio, Deborah Konopnicki, Lurdes Santos, Alper Sener, Sukran Kose, Corneliu Popescu, Nefise Oztoprak, Guven Celebi, Derya Ozturk-Engin, Xavier Argemi, Jamal Wadi, Meltem Avci, Nicolas Dauby, Yasemin Cag, Ilkay Bozkurt, Recep Tekin, Imran Hasanoglu, Ejaz Ahmed Khan, Rahmet Guner, Fahad AlmajidNesrin Ghanem-Zoubi, Aysegul Erdem, Edmond Puca, Irina Magdalena Dumitru, Meliha Meric-Koc, Hacer Deniz Ozkaya, André Silva-Pinto, Ayse Sagmak-Tartar, Meltem Tasbakan, Abdullah Umut Pekok, Ayse Kaya-Kalem, Serkan Oncu, Jesper Damsgaard Gunst, Rosa Fontana Del Vecchio, Guven Celebi, Simin Florescu, Yvon Ruch, Raquel Duro, Safak Ozer-Balin, Mustafa Dogan, Nicola Petrosillo, Corneliu Popescu, Sema Sari, Sumeyra Karakus, Tatjana Lejko Zupanc, Arjeta Dedej, Oday Abu Ajamieh, Necla Tulek, Sema Sari, Pedro Palma Martins, Jamal Wadi, Ilker Inanc Balkan, Gilda Tonziello, Najada Como, Ayse Batirel, Canan Agalar, Necla Tulek, Selma Tosun, Fatma Sirmatel, Atilla Iyisoy, Jean-Philippe Mazzucotelli, Yves Hansmann, Gulden Ersoz, Hakan Erdem, Pedro Palma Martins, Serda Gulsun, Asuman Inan

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2 Citations (Scopus)

Abstract

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
Original languageEnglish
Number of pages11
JournalEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Cascio, A., Konopnicki, D., Santos, L., Sener, A., Kose, S., Popescu, C., Oztoprak, N., Celebi, G., Ozturk-Engin, D., Argemi, X., Wadi, J., Avci, M., Dauby, N., Cag, Y., Bozkurt, I., Tekin, R., Hasanoglu, I., Khan, E. A., Guner, R., ... Inan, A. (2019). Portraying infective endocarditis: results of multinational ID-IRI study. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.