Persistence of Nonceliac Wheat Sensitivity, Based on Long-term Follow-up

Ada Maria Florena, Pasquale Mansueto, Girolamo Geraci, Maurizio Soresi, Antonio Carroccio, Francesca Fayer, Alberto D'Alcamo, Ada M. Florena, Antonio Carroccio, Rosario Iacobucci, Francesco La Blasca, Andrea Arini, Pasquale Mansueto, Francesca Cavataio, Giuseppe Iacono, Maurizio Soresi, Girolamo Geraci, Alberto D'Alcamo, Anna Arini, Francesca CavataioFrancesca Fayer

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17 Citations (Scopus)


We investigated how many patients with a diagnosis of nonceliac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy; 148 of these individuals were still on a strict wheat- free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared with 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P < .0001). Of the 22 patients who repeated the double-blind, placebo- controlled challenge, 20 reacted to wheat. We conclude that NCWS is a persistent condition. registration number: NCT02823522.
Original languageEnglish
Pages (from-to)56-58
Number of pages3
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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