Perfluorocarbon functionalized hyaluronic acidderivatives as oxygenating systems for cell culture

Mauro Di Stefano, Calogero Fiorica, Fabio Salvatore Palumbo, Gaetano Giammona, Silvestre Buscemi, Antonio Palumbo Piccionello, Giovanna Pitarresi, Ivana Pibiri, Mauro Di Stefano, Ivana Pibiri, Buscemi, Giovanna Pitarresi, Giammona, Antonio Palumbo Piccionello

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


A set of new hyaluronic acid (HA) derivatives was obtained by binding fluorinated oxadiazole (OXA) moietiesto an amino derivative of the polysaccharide (HA-EDA). The obtained HA-EDA-OXA biomaterials arepotentially able to improve oxygenation into a scaffold for tissue engineering purposes. The oxygensolubility in aqueous dispersions of the obtained derivatives showed that polymers were able to improveoxygen uptake and maintenance in the medium. The HA-EDA-OXA was employed to form a hydrogelin situ by reaction with a vinyl sulphone derivative of inulin, under physiological conditions. The influenceof the presence of OXA moieties on the mechanical properties of the obtained hydrogels as well as onthe metabolic activity of incorporated primary fibroblasts was investigated. The produced HA-EDA-OXAbiomaterials were able to promote cell growth under hypoxic conditions.
Original languageEnglish
Pages (from-to)22894-22901
Number of pages8
JournalRSC Advances
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering


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