Poly[monomethylnona(ethylene glycol) 1-methylene-3-(4-methylphenyl)-1H-indene-2-carboxylate](poly-1b) a new polymer based on a PEG-functionalized benzofulvene macromonomer have been investigatedas hydrogel-based material for complexation and release of immunoglobulin (IgG) at physiologicalmimicking conditions.The polymer ability to complex human IgG has been studied by preparing copolymer/protein complexesobtained by spontaneous protein interactions onto polymer hydrogel aggregates, and the proteinrelease rate has been evaluated at physiological conditions. SEM analysis was used to visualize thecopolymer/IgG aggregates and its microstructured deposition. Moreover, rheological studies performedat 37 ◦C allowed determining hydrogel mechanical properties. On the basis of these information and NMRtransverse relaxation measurements, the estimation of hydrogel mesh size distribution was possible.Finally, biological studies performed with poly-1b aqueous dispersions showed no cytotoxic effect onMCF-7 cell line, suggesting potential biocompatibility features for this polymer and making this newpolymer a good potential candidate for the production of drug delivery systems.
|Number of pages||8|
|Journal||International Journal of Pharmaceutics|
|Publication status||Published - 2010|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science