INTRODUCTION: Obesity is a well-known risk factorfor the development and progression of chronic kidneydisease. Recently, para-perirenal ultrasonographic fatthickness (PUFT) has shown to correlate with both total and visceral fat better than body mass index (BMI), waistcircumference (WC) and other indices of obesity. Moreover,a local paracrine and mechanical action of the PUFTon kidney has been described in recent studies.AIM: To assess the relationship between glomerular filtrationrate (GFR) and PUFT in comparison to otheranthropometric and ultrasonographic indices of adiposity.METHODS: Two hundred ninety-six hypertensive patientswere enrolled. PUFT, cutis-rectis thickness and rectis-aortathickness were obtained by ultrasonography. Anthropometricmeasures of adiposity were also measured. Estimated GFRwascalculated using the CKD-EPI equation.RESULTS: Higher PUFT values were observed in patientswith impaired renal function (p.001), whereas no differencesin BMI and WC were shown between groupsdivided by GFR. PUFT significantly correlated with GFRin all subjects (r = - 0.284; p.001), with no differencesin groups divided by gender, diabetes or BMI. Thisassociation held in multivariate analyses also after correctionfor confounding factors, including other adiposityindices (p.001). When receiver-operating characteristiccurves were built to detect a eGFR0 ml/min/1.73 m2, a PUFT value B 3.725 cm showed a negativepredictive value of 94.0%, with the largest area under thecurve (AUC: 0.700) among the variables considered.CONCLUSIONS: the relationship between PUFT andGFR seems to be more accurate and less influenced by thebias affecting traditional indices of adiposity.
|Number of pages||2|
|Journal||HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION|
|Publication status||Published - 2018|
Mattina, A., Cottone, S., Mule', G., Geraci, G., Pugliares, C., Cusumano, C., Zammuto, M. M., & Tranchida, V. (2018). PARA-PERIRENAL DISTRIBUTION OF BODY FATIS ASSOCIATED WITH REDUCED GLOMERULARFILTRATION RATE REGARDLESS OF OTHERINDICES OF ADIPOSITY IN HYPERTENSIVESUBJECTS Selected Abstracts from XXXV National Congress of the Italian Society of Hypertension (SIIA), Rome, 27-29 September 2018. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 25, 62-63.