An extension of the ‘Cusmano–Ruccia’ reaction is reported. 6-(4-chlorophenyl)-3-methyl-5-nitrosoimi-dazo[2,1-b]oxazole by the action of hydrochloric acid gives 3-(4-chlorobenzoyl)-5-methyl-1,2,4-oxadiaz-ole (13); presumably via ammonium ion, CO2 and methanol elimination. The relevance of the nature of the atom of the B-ring linked to C-2 of the imidazole for the occurrence of the ring-into-ring interconver-sion has been once more conﬁrmed.
|Number of pages||3|
|Publication status||Published - 2014|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry