On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions

Maria Antonietta Sabatino, Clelia Dispenza, Natascia Grimaldi, Marta Walo, Dispenza, Murugan, Maria Rosalia Mangione, Jonsson

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
Original languageEnglish
Pages (from-to)2582-2591
Number of pages10
JournalRSC Advances
Volume6
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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