Nuovi inibitori di Aurora chinasi A come target biologico coinvolto nei processi carcinogenici

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Abstract

[automatically translated] Identifying Aurora kinase A as a favored target for the expansion of tumor inhibition was used the computational approach to perform a virtual screening of a library "in house" of molecular structures. The computational analysis of data allowed to identify the derivatives of the series pyrido [3 ', 2': 4,5] furo [3,2-d] -1,2,3-triazin-4 (3H) -one type 3 new compounds to potential inhibitory activity on the ATP-asico site of Aurora kinase A. the synthesis of the tricyclic-heteroaromatic system 3 provides for the diazotization of 3-amino-1 furopiridina and subsequent coupling reaction with a series of suitably chosen primary amines, allowing the isolation of the 3-triazeno-furopiridine 2. the derivatives triazenici 2, molecules which in themselves have already amply documented in the literature a profound anti-tumor activity,
Original languageItalian
PagesP26-
Number of pages1
Publication statusPublished - 2011

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