NREM Sleep Instability in Pediatric Migraine Without Aura

Michele Roccella, Daniela Smirni, Giovanni Messina, Francesco Precenzano, Carla Loreto, Vincenzo Russo, Monica Salerno, Francesco Sessa, Ilaria Bitetti, Giulio Di Mizio, Vincenzo Russo, Vincenzo Russo, Francesca Felicia Operto, Paolo Murabito, Giulio Di Mizio, Diego Iacono, Beatrice Gallai, Marco Carotenuto, Maria Esposito, Rosa Marotta

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6 Citations (Scopus)

Abstract

Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; p ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) (p = 0.008). In particular, MoA children showed a reduced CAP rate% (p ≤ 0.001), CAP rate% in S1 (p ≤ 0.001) and CAP rate% in SWS (p = 0.004) vs. C. Moreover, A phases distribution were characterized by a reduction in slow wave components (total number CAP A1%, CAP A1 index) (p ≤ 0.001) and an increase of fast components representation (total number of CAP A2% and CAP A3%) (p < 0.001) in MoA vs. C. Moreover, MoA children showed an increased A1 and A2 mean duration (p ≤ 0.001). Our findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.
Original languageEnglish
Number of pages6
JournalFrontiers in Neurology
Volume10
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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