Notch 1 pathway and EPCs in bicuspid aortic valve: is their interplay involved in the ascending aortic aneurysm onset?

Domenico Lio, Carmela Rita Balistreri, Calogera Pisano, Floriana Crapanzano

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Backgroud_AIM: Bicuspid aortic valve (BAV) isfrequently associated with development of ascendingaortic aneurysm, even if the underlying mechanismsremain to be clarified. Here, we investigated if aderegulation of Notch1 signaling pathway andendothelial progenitor cells (EPCs) number is associatedwith BAV disease and an early ascending aorticaneurysm (AAA) onset.Methods: To this aim,70 subjects with BAV (M/F 50/20;mean age: 58.8±14.8 years) and 70 subjects with tricuspidaortic valve (TAV)(M/F 35/35; mean age: 69.1±12.8years), AAA complicated or not, were enrolled.Multiparametric flow cytometry analyses, plasma amountassessments, gene expressions, and tissue protein semiquantitativeevaluations were also performed.Results:Interestingly, patients with AAA showed asignificant increase in circulating Notch1 levels and EPCnumber than subjects without AAA. However, circulatingNotch1 levels and EPC number were significantly lower inBAV subjects than TAV patients either in the presence orabsence of AAA. Finally, Notch pathway was activated toa greater extent in aortic aneurysmatic portions withrespect to healthy aortic fragments in both BAV and TAVpatients. However, the expression of genes encodingcomponents and ligands of Notch pathway in aortic tissueswas significantly lower in BAV than TAV subjects.CONCLUSION: Our study demonstrates that BAVsubjects are characterized by a significant decrease in bothtissue and circulating levels of Notch pathway, and inblood EPC number than TAV patients, either in presenceor absence of AAA disease.
Original languageEnglish
Pages (from-to)68-68
Number of pages1
Publication statusPublished - 2018


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