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37 Citations (Scopus)


Nitric oxide (NO) is a gaseous messenger involvedin atypical forms of intercellular communications, able to exerta strong functional modulation of several neurotransmittersystems. In particular, NO heavily influences the excitatoryneurotransmitter glutamate, mainly through NMDA receptors,and the inhibitory neurotransmitter GABA, mainly throughGABA A receptors. Due to the involvement of glutamate andGABA in a delicate balance conditioning the functional statusof the neural cells, this interaction suggests a role for NO inregulating neuronal excitability and its transition towardshyperexcitability phenomena. This article reviews the mainknowledge about the relationships existing between the activityof the NO system and the experimental aspects of epilepsy,focusing on the somewhat antithetic findings about theproconvulsant or the anticonvulsant roles exerted by nitric oxide.
Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalIn Vivo
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology


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