Neuromuscular disorders and non compaction: How much is the strength of the association and how can it be suspected?

Giuseppina Novo, Salvatore Novo, Claudia Luisa Visconti, Giovanni Fazio, Luciana D'Angelo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


In many reports Finsterer and Stöllberger reported a strong association between non compaction of the left ventricle and neuromuscular disorders. In the same report the authors described a neurological involvement in more than 50%. Recently we published our personal experience, about 21 paediatric patients: only 4 patients (19%) showed a neuromuscular disorder, and only 1 of them showed an increased plasmatic level of CK, and in particular of MM isoform, with a normal level of CK-MB. None presented high levels of troponine. Through the experience of 3 centres we collected 61 patients affected by non compaction that performed a neurological control, and only 14 (21%) were affected by neuromuscular disorders. A correlation between neuromuscular disorders and cardiac non compaction is present, even if, until today, genetic involvement has not been identified clearly. However, in our opinion, an estimated incidence of 50% of neuromuscular disorders in this population of patients could be too exaggerated. About the prognostic value of the CK elevation, it is interesting to consider that an increasing of CK plasmatic level is an expression of muscular disorders and not of cardiac alterations. In our experience only 1 patient in 21 patients (4%) with neuromuscular disorders showed an increasing of CK-MM plasmatic value.
Original languageEnglish
Pages (from-to)215-216
Number of pages2
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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