Networks in biological systems: An investigation of the Gene Ontology as an evolving network

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Abstract

Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.
Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalIL NUOVO CIMENTO C
Volume32
Publication statusPublished - 2009

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Biological systems
Ontology
Genes

All Science Journal Classification (ASJC) codes

  • Astronomy and Astrophysics
  • Physics and Astronomy (miscellaneous)

Cite this

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title = "Networks in biological systems: An investigation of the Gene Ontology as an evolving network",
abstract = "Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.",
author = "Mantegna, {Rosario Nunzio} and Michele Tumminello and Claudia Coronnello and Salvatore Micciche'",
year = "2009",
language = "English",
volume = "32",
pages = "157--160",
journal = "Nuovo Cimento della Societa Italiana di Fisica C",
issn = "2037-4909",
publisher = "Editrice Compositori s.r.l.",

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T1 - Networks in biological systems: An investigation of the Gene Ontology as an evolving network

AU - Mantegna, Rosario Nunzio

AU - Tumminello, Michele

AU - Coronnello, Claudia

AU - Micciche', Salvatore

PY - 2009

Y1 - 2009

N2 - Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.

AB - Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.

UR - http://hdl.handle.net/10447/44551

M3 - Article

VL - 32

SP - 157

EP - 160

JO - Nuovo Cimento della Societa Italiana di Fisica C

JF - Nuovo Cimento della Societa Italiana di Fisica C

SN - 2037-4909

ER -