Neonatal liver abscesses associated with candidemia: three cases and review of literature

Antonio Cascio, Orazio Romeo, Giuseppina Barberi, Dario Pantaleo, Demetrio Delfino, Ignazio Barberi, Antonio Cascio, Giuseppina Corona, Chiara Iaria

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

AbstractBACKGROUND:Our aim was to identify risk factors for the development of neonatal Candida liver abscess and to find useful information to better manage this potentially fatal complication.METHODS:A computerized search was conducted using PubMed. Overall, three articles describing the history of seven infants were finally considered. The characteristics of these seven cases were analyzed together with those of three new cases that we treated in the recent past.RESULTS:All the neonates were premature. Previous antibiotic use was reported in all the cases, umbilical venous catheterization in 9/10 and total parenteral nutrition in 8/10. Candida albicans was isolated in 9/10. All the patients presented with aspecific signs of sepsis. Liver abscesses were described as "microabscesses" or "miliary abscesses" in three cases, as solitary lesion in two cases. In one case two lesions and in one four lesions were reported. Three infants died.CONCLUSIONS:Liver ultrasonography should be performed in all the neonates with signs of sepsis, especially in the presence of candidemia and/or hepatomegaly and/or significant change in liver enzymes. Umbilical venous catheter should be removed, and peripheral IV access should be used until there is documented clearance from the blood with three or more negative blood cultures.
Original languageEnglish
Pages (from-to)943-949
Number of pages7
JournalTHE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume27
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • General Medicine
  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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