Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release

Filippo Parisi, Stefana Milioto, Giuseppe Lazzara, Giuseppe Cavallaro, Rawil Fakhrullin, Vladimir Evtugyn, Elvira Rozhina

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)


An easy strategy to obtain nanohydrogels within the halloysite nanotube (HNTs) lumen was investigated. Inorganic reverse micelles based on HNTs and hexadecyltrimethylammonium bromides were dispersed in chloroform, and the hydrophilic cavity was used as a nanoreactor to confine the gel formation based on alginate cross-linked by calcium ions. Spectroscopy and electron microscopy experiments proved the confinement of the polymer into the HNT lumen and the formation of calcium-mediated networks. Biological tests proved the biocompatibility of the hybrid hydrogel. The nanogel in HNTs was suitable for drug loading and sustained release with the opportunity of triggered burst release by chemical stimuli. Here, we propose a new strategy based on inorganic reverse micelles for nanohydrogel formation, which are suitable for industrial and biological applications as well as for selective and triggered adsorption and/or release. © 2018 American Chemical Society.
Original languageEnglish
Pages (from-to)8265-8273
Number of pages9
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • General Materials Science


Dive into the research topics of 'Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release'. Together they form a unique fingerprint.

Cite this