Nab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life

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Abstract

Objective: Metastatic breast cancer (MBC) is an incurable disease; the treatment of thisdisease prolongs survival, improving the quality of life (QoL) with a balance between efficacyand toxicity of the treatment. In recent years, treatment with nab-paclitaxel has improved thealready known antitumor activity of conventional paclitaxel, in terms of increased efficacyand better tolerability. The aim of this study was to evaluate nab-paclitaxel in Italian patientswith MBC.Methods: We conducted a retrospective analysis of 90 patients with histologically confirmed diagnosis of MBC. To evaluate the efficacy of nab-paclitaxel, overall survival (OS),progression-free survival (PFS), and overall response rate were the primary endpoints,whereas carbohydrate antigen 15.3 (Ca15.3) reduction, QoL, and tolerability were secondary endpoints.Results: The median OS was 10.4 months, the median PFS was 6.8 months. A considerabledifference Ca15.3 before and after treatment was observed. Descriptive and regression analyseswere done to examine the associations between Ca15.3 response and OS, demonstrating goodcorrelation, revealing that Ca15.3 reduction is an important predictor of OS.Conclusion: Nab-paclitaxel is an effective and well-tolerated treatment of patients affected byMBC. The drug showed an improved tolerability profile. With all the limitations of the observational nature of our results, nab-paclitaxel has proven to be an effective and safe therapeuticoption in patients with MBC.
Original languageEnglish
Pages (from-to)1621-1627
Number of pages7
JournalOncoTargets and Therapy
Volume12
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

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