Multiple Roles for ISWI in Transcription, Chromosome Organization and DNA Replication

Davide Corona, Davide F.V. Corona, John W. Tamkun

Research output: Contribution to journalArticlepeer-review

149 Citations (Scopus)

Abstract

ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalBIOCHIMICA ET BIOPHYSICA ACTA, N. GENE STRUCTURE AND EXPRESSION
Volume1677
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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