Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Toscani, D.; Giuliani, N.

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis.
Original languageEnglish
Pages (from-to)2-00
Number of pages15
JournalJOURNAL OF HEMATOLOGY & ONCOLOGY
Volume12
Publication statusPublished - 2019

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