Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations

Giuditta Gambino, Manuel Valero, Adan De Salas-Quiroga, Elena Cid, Giuditta Gambino, Liset M. De La Prida, Andrea Navas-Olive, Teresa Jurado-Parras, Robert G. Averkin, Liset M. De La Prida

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Theta oscillations play a major role in temporarily defining the hippocampal rate code by translating behavioral sequences into neuronal representations. However, mechanisms constraining phase timing and cell-type-specific phase preference are unknown. Here, we employ computational models tuned with evolutionary algorithms to evaluate phase preference of individual CA1 pyramidal cells recorded in mice and rats not engaged in any particular memory task. We applied unbiased and hypothesis-free approaches to identify effects of intrinsic and synaptic factors, as well as cell morphology, in determining phase preference. We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by unsupervised methods demonstrated that firing selection is tuneable across sublayers. Our data identify different mechanisms of phase-locking selectivity that are instrumental for flexible dynamical representations of theta sequences.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalNature Communications
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy

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