Microfluidic production of hyaluronic acid derivative microfibers to control drug release

Giovanna Pitarresi, Gaetano Giammona, Stefano Agnello, Fabio Salvatore Palumbo, João F. Mano, Luca Gasperini, Rui L. Reis, Rui L. Reis, Luca Gasperini, Giovanna Pitarresi, Gaetano Giammona

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.
Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalMaterials Letters
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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