MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease

Salvatore Petta, Calogero Camma', Alessandro Gulino, Stefania Grimaudo, Claudio Tripodo, Antonio Craxi, Rosaria Maria Pipitone, Raffaela Rametta, Fabio Marra, Andrea Cappon, Luca Valenti, Paola Dongiovanni, Enrico Mozzi, Elisabetta Bugianesi, Marco Maggioni, Luca Valenti, Silvia Fargion, Giovanni Di Maira, Emanuele Orlando

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65 Citations (Scopus)

Abstract

Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK has been associated with protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with NAFLD. We also investigated whether MERTK is expressed in human hepatic stellate cells (HSC) and in murine models of fibrogenesis.
Original languageEnglish
Number of pages9
JournalJournal of Hepatology
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Hepatology

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