Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Riccardo Di Fiore, Renza Vento, Nichola Cruickshanks, Hosni K. Salem, Roslida A. Hamid, Dale W. Laird, Stefano Forte, Harini Krishnan, Rafaela Andrade-Vieira, Rabeah Al-Temaimi, Dustin G. Brown, Richard Ponce-Cusi, Sarah Bay, Elizabeth P. Ryan, Rabindra Roy, Lorenzo Memeo, Jordan Woodrick, Ivana Scovassi, Neetu Singh, Mark WadeAnnamaria Colacci, Lorenzo Memeo, Neetu Singh, Amedeo Amedei, Fahd Al-Mulla, Karine A. Cohen-Solal, Rita Nahta, Paola A. Marignani, Chiara Mondello, Gloria M. Calaf, Monica Vaccari, Jayadev Raju, Renza Vento, Christian C. Naus, Jan Vondráček, Paul Dent, Gary S. Goldberg, Debasish Roy, Ahmed Lasfar, Robert C. Castellino, William H. Bisson

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Original languageEnglish
Pages (from-to)S2-S18
Number of pages17
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Cancer Research


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