May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

Eleonora Russo, Yuji Kaneko, Paul R Sanberg, Hung Nguyen, Jea-Young Lee, Trenton Lippert, Kaya Xu, Eleonora Russo, Julian Tuazon, Eleonora Napoli, Cesar V Borlongan

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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