Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study

Fortunato Siracusa, Paolo D'Angelo, Alessandro Inserra, Patrizia Dall' Igna, Gian Luca Babbo, Fortunato Siracusa, Giovanna Riccipetitoni, Monica Terenziani, Maria Debora De Pasquale, Paolo Indolfi, Gianni Bisogno, Luigi Piva, Paolo Tamaro, Filippo Spreafico, Giovanni Cecchetto, Renata Boldrini, Massimo Conte

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    19 Citations (Scopus)


    Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocolfor malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with amalignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a secondmetachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions. Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery inimmature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.
    Original languageEnglish
    Pages (from-to)13-19
    Number of pages7
    Publication statusPublished - 2015

    All Science Journal Classification (ASJC) codes

    • Pediatrics, Perinatology, and Child Health
    • Hematology
    • Oncology


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