Markers of inflammation are strong predictors of subclinical and clinical atherosclerosis in women with hypertension.

Manfredi Rizzo, Egle Corrado, Salvatore Novo, Giuseppina Novo, Salvatore Novo, Giuseppe Coppola, Giuseppina Novo, Manfredi Rizzo, Egle Corrado, Ida Muratori, Giuseppe Coppola, Ida Maria Muratori

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35 Citations (Scopus)


Cardiovascular diseases in women still rises and remainstheir leading cause of death in most developed countries;yet we have less sex-specific data in women than in menas a result of lower enrollment in clinical trials and lowrates of sex-specific reporting. The aim of our study wasto evaluate in hypertensive postmenopausal women thepotential predictive role of markers of inflammation, forexample, fibrinogen and C-reactive protein (CRP), onsubclinical and clinical atherosclerosis, beyond that of theother established cardiovascular risk factors. We studied127 asymptomatic hypertensive postmenopausal womenwith different degrees of carotid intima–media thickness,as examined by the eco-color-doppler ultrasonography,evaluating in a 5 years follow-up cerebrovascular andcardiovascular morbidity and mortality. We preliminarilyfound that both fibrinogen and CRP levels were associatedwith the extension of carotid atherosclerosis (P < 0.0001and P= 0.0445, respectively). We also found that amongall established traditional cardiovascular risk factors(including obesity, diabetes, smoking habit, family historyof coronary artery disease, dyslipidemia) only older age(P = 0.0162), elevated fibrinogen (P = 0.0298), and CRP(P = 0.0345) were independent predictors of subclinicalatherosclerosis. At the end of follow-up patients clinicalevents were registered in the 24% of patients andmultivariate analysis revealed the following predictors of events: elevated CRP levels [odds ratio (OR): 12.6],the presence of family history of coronary arterydisease(OR: 8.8) and older age (OR: 1.1). Beyond theutility of CRP and fibrinogen levels in the predictionof subclinical and clinical atherosclerosis, the therapeuticimplications of these results remain to be evaluatedby further studies
Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalCoronary Artery Disease
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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