Management of Venous ThromboEmbolism in patients with acute leukemia at high bleeding risk: a multicenter study

Sergio Siragusa, Mariasanta Napolitano, Alessandra Casuccio, Alessandra Malato, Alessandro Lucchesi, Donato Mannina, Calogero Vetro, Anna Candoni, Maria Ilaria Del Principe, Francesco Fabbiano, Francesco Di Raimondo

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9 Citations (Scopus)

Abstract

In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
Original languageEnglish
Pages (from-to)1-13-13
Number of pages13
JournalLEUKEMIA & LYMPHOMA
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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