Management of kidney transplantation in a factor VII-deficient patient: case report.

Mariasanta Napolitano, Aloisio, Ferraresi, Famulari, Mirko Pinotti, Mario Lapecorella, Rizza, Clemente, Di Cocco, Alessandro Lucchesi, Francesco Bernardi, Pisani, Mariasanta Napolitano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.
Original languageEnglish
Pages (from-to)-
Number of pages2
JournalTransplantation Proceedings
Volume44
Publication statusPublished - 2012

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Factor VII
Kidney Transplantation
Factor VIIa
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Organ Transplantation
Hemorrhage
Appointments and Schedules
Factor VII Deficiency
Hemorrhagic Disorders
Chronic Kidney Failure
Therapeutics
Transplantation
Safety

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Napolitano, M., Aloisio, Ferraresi, Famulari, Pinotti, M., Lapecorella, M., ... Napolitano, M. (2012). Management of kidney transplantation in a factor VII-deficient patient: case report. Transplantation Proceedings, 44, -.

Management of kidney transplantation in a factor VII-deficient patient: case report. / Napolitano, Mariasanta; Aloisio; Ferraresi; Famulari; Pinotti, Mirko; Lapecorella, Mario; Rizza; Clemente; Di Cocco; Lucchesi, Alessandro; Bernardi, Francesco; Pisani; Napolitano, Mariasanta.

In: Transplantation Proceedings, Vol. 44, 2012, p. -.

Research output: Contribution to journalArticle

Napolitano, M, Aloisio, Ferraresi, Famulari, Pinotti, M, Lapecorella, M, Rizza, Clemente, Di Cocco, Lucchesi, A, Bernardi, F, Pisani & Napolitano, M 2012, 'Management of kidney transplantation in a factor VII-deficient patient: case report.', Transplantation Proceedings, vol. 44, pp. -.
Napolitano, Mariasanta ; Aloisio ; Ferraresi ; Famulari ; Pinotti, Mirko ; Lapecorella, Mario ; Rizza ; Clemente ; Di Cocco ; Lucchesi, Alessandro ; Bernardi, Francesco ; Pisani ; Napolitano, Mariasanta. / Management of kidney transplantation in a factor VII-deficient patient: case report. In: Transplantation Proceedings. 2012 ; Vol. 44. pp. -.
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AU - Lapecorella, Mario

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