Malignant epithelial/exocrine tumors of the pancreas

Ada Maria Florena, Sara Pecori, Matteo Fassan, Paola Parente, Alessandro Vanoli, Federica Grillo, Claudio Luchini, Giuseppe Ingravallo, Gaetano Paolino, Aldo Scarpa, Paola Mattiolo, Giuseppe Zamboni, Aldo Scarpa, Alessandro D'Amuri, Giuseppina Renzulli, Paola Capelli, Claudio Doglioni, Giuseppe Zamboni, Alessandro D'Amuri

Research output: Contribution to journalArticlepeer-review


Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.
Original languageEnglish
Pages (from-to)210-226
Number of pages17
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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