TY - JOUR
T1 - Malignant epithelial/exocrine tumors of the pancreas
AU - Florena, Ada Maria
AU - Pecori, Sara
AU - Fassan, Matteo
AU - Parente, Paola
AU - Vanoli, Alessandro
AU - Grillo, Federica
AU - Luchini, Claudio
AU - Ingravallo, Giuseppe
AU - Paolino, Gaetano
AU - Scarpa, Aldo
AU - Mattiolo, Paola
AU - Zamboni, Giuseppe
AU - Scarpa, Aldo
AU - D'Amuri, Alessandro
AU - Renzulli, Giuseppina
AU - Capelli, Paola
AU - Doglioni, Claudio
AU - Zamboni, Giuseppe
AU - D'Amuri, Alessandro
PY - 2020
Y1 - 2020
N2 - Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.
AB - Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.
KW - PDAC
KW - acinar
KW - pancreatic cancer
KW - pancreatic ductal adenocarcinoma
KW - solid pseudopapillary.
KW - PDAC
KW - acinar
KW - pancreatic cancer
KW - pancreatic ductal adenocarcinoma
KW - solid pseudopapillary.
UR - http://hdl.handle.net/10447/443575
M3 - Article
VL - 112
SP - 210
EP - 226
JO - Pathologica
JF - Pathologica
SN - 0031-2983
ER -