Malattia di Dupuytren

Francesco Moschella, Massimiliano Tripoli

Research output: Book/ReportBook

Abstract

[automatically translated] Dupuytren's disease still remains shrouded in mystery: it is uncertain paternity of his first description, though, and with much controversy, as centoottantuno years is historically linked to the illustrious French surgeon Guillaume Dupuytren. An enigma for scholars is also its etiology, where environmental factors, behavioral, genetic, and molecular biology, in part still unknown, interact at multiple levels, generating a cascade of biochemical reactions that lead to the well known overgrowth of fibroblasts and the resulting deposition of collagen. It also represents a challenge for the surgeon who must wade through different surgical techniques in relation to the stage of the disease, age of patient, daily living needs, in a district that for anatomical complexity is unparalleled in the rest of the body. Until now surgery has been the only encoded therapeutic option that has allowed to obtain the correction of long-term digital deformity. Encouraging results have been achieved recently with collagenase, which still do not exist statistically significant long-term results. further studies and investigations are still needed that require contributions and collaborations among the "various fields of knowledge? in order to find less and less invasive solutions for the definitive treatment of this disease. further studies and investigations are still needed that require contributions and collaborations among the "various fields of knowledge? in order to find less and less invasive solutions for the definitive treatment of this disease. further studies and investigations are still needed that require contributions and collaborations among the "various fields of knowledge? in order to find less and less invasive solutions for the definitive treatment of this disease.
Original languageItalian
PublisherElsevier
Number of pages230
ISBN (Print)9788821434679
Publication statusPublished - 2012

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