232 Citations (Scopus)

Abstract

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in r3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses
Original languageEnglish
Pages (from-to)2406-2447
Number of pages42
JournalChemical Society Reviews
Volume41
Publication statusPublished - 2012

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Lewis Bases
Lewis Acids
Catalysis
Hydrogen bonds
Acids
carbene

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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title = "Low-loading asymmetric organocatalysis",
abstract = "Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in r3 mol{\%} loading in all the sub-areas of the field, namely aminocatalysis, Br{\o}nsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses",
keywords = "oragnocatalysis; phase-transfer catalysis; Bronsted acids; Bronsted Bases; Aminocatalysis",
author = "Renato Noto and Michelangelo Gruttadauria and Paola Agrigento and Francesco Giacalone",
year = "2012",
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volume = "41",
pages = "2406--2447",
journal = "Chemical Society Reviews",
issn = "0306-0012",
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T1 - Low-loading asymmetric organocatalysis

AU - Noto, Renato

AU - Gruttadauria, Michelangelo

AU - Agrigento, Paola

AU - Giacalone, Francesco

PY - 2012

Y1 - 2012

N2 - Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in r3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses

AB - Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in r3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses

KW - oragnocatalysis; phase-transfer catalysis; Bronsted acids; Bronsted Bases; Aminocatalysis

UR - http://hdl.handle.net/10447/62124

M3 - Article

VL - 41

SP - 2406

EP - 2447

JO - Chemical Society Reviews

JF - Chemical Society Reviews

SN - 0306-0012

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