Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity

Carmela Rita Balistreri, Elena Cavarretta, Giacomo Frati, Sebastiano Sciarretta

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Abstract

Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This changing paradigm has clearly emerged in the recently released American Association for Thoracic Surgery (AATS) consensus guidelines focusing on bicuspid aortic valve-related aortopathy, which covered all major aspects of BAV
Original languageEnglish
Pages (from-to)113-114
Number of pages2
JournalJournal of Molecular and Cellular Cardiology
Volume133
Publication statusPublished - 2019

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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