Levo folinic acid and 5-fluorouracil plus high dose epidoxorubicin as first line treatment for metastatic breast carcinoma

Vittorio Gebbia, Nicolo' Gebbia, Mario Latteri, Calogero Cipolla, Nicola Gebbia, Vittorio Gebbia, Carmela Amato, Matteo Florena, Valenza, Amato, Calogero Cipolla, Mario A. Latteri, Testa

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3 Citations (Scopus)

Abstract

Twenty-two women affected by metastatic breast carcinoma have been treated with a combination of levo folinic acid 100 mg/m 2 plus 5-fluorouracil 450 mg/m 2 i.v. on day 1-2, and epidoxorubicin 75-90 mg/m 2 on day 2. This treatment cycle was repeated every 21-28 days. No patients had previously received chemotherapy for metastatic disease. Fourteen patients (64%) showed a major objective response with 3 complete (14%) and 11 partial responses (50%). Three patients showed a stabilization of disease and 5 (23%) progressed. All patients received ondansetron as antiemetic treatment which led to complete protection from vomiting in 68% of cases. Grade 1-2 diarrhea was recorded in 27% of the patients. Ten patients received recombinant human granulocyte-colony stimulating factor (rhG-CSF) as leukopenia-preventive treatment. In this group of patients the interval between chemotherapeutic cycles was shorter than in the group of 12 patients who did not receive rhG-CSF.
Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalAnticancer Research
Volume13
Publication statusPublished - 1993

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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