Left ventricular hypertrophy or storage disease? the incremental value of speckle tracking strain bull's-eye

Giuseppina Novo, Roberta Esposito, Andrea Rossi, Matteo Cameli, Eduardo Bossone, Juri Radmilovic, Antonello D'Andrea, Giuseppina Novo, Roberta Montisci, Sergio Mondillo, Eustachio Agricola, Sabina Gallina, Maurizio Galderisi, Donato Mele, Piercarlo Ballo

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Left ventricular hypertrophy (LVH) develops in response to a variety of physical, genetic, and biochemical stimuli and represents the early stage of ventricular remodeling. In patients with LVH, subclinical left ventricular (LV) dysfunction despite normal ejection fraction (EF) may be present before the onset of symptoms, which portends a dismal prognosis. Strain measurement with two-dimensional speckle tracking echocardiography (STE) represents a highly reproducible and accurate alternative to LVEF determination. The present review focuses on current available evidence that supports the incremental value of STE in the diagnostic and prognostic workup of LVH. When assessing the components of LV contraction, STE has an incremental value in differentiating between primary and secondary LVH and in the differential diagnosis with storage diseases. In addition, STE provides unique information for the stratification of patients with LVH, enabling to detect intrinsic myocardial dysfunction before LVEF reduction.
Original languageEnglish
Pages (from-to)746-759
Number of pages14
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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