LATE-ONSET OCULAR HYPERTENSION after VITRECTOMY: A Multicenter Study of 6,048 Eyes

Vincenza Maria Elena Bonfiglio, Mario R. Romano, Andrea Russo, Gilda Cennamo, Matteo Fallico, Niccolò Castellino, Guglielmo Parisi, Matteo Fallico, Vincenza Bonfiglio, Michele Reibaldi, Francesco Boscia, Giovanni Li Volti, Teresio Avitabile, Claudio Bucolo, Cesare Mariotti, Antonio Longo, Andrea Russo, Francesco Boscia, Giovanni Li Volti

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3 Citations (Scopus)


Purpose: To determine the incidence and risk factors for late-onset ocular hypertension (LOH) after vitrectomy. Methods: From the electronic medical records of consecutive patients who underwent primary vitrectomy, from January 2010 to December 2015, at 5 tertiary vitreoretinal centers in Italy, patient demographics, systemic, ophthalmic, operative, and postoperative data were drawn. Main outcome measure was the presence of LOH, defined as intraocular pressure >21 mmHg detected more than 2 months after vitrectomy on at least 2 consecutive visits. Results: Among 6,048 patients, LOH was found in 294 (4.9%) vitrectomized eyes and in 87 (1.4%) fellow eyes, (chi square; P < 0.001). Multivariable logistic regression showed that significant risk factors for developing LOH included intraoperative triamcinolone use (odds ratio [OR], 7.62; P < 0.001), longer axial length (OR, 1.55; P = 3.023), preoperative higher intraocular pressure (OR, 1.81; P = 0.003), and postvitrectomy pseudophakic/aphakic status (OR, 2.04; P < 0.001). Decision-tree analysis showed that the stronger predictor of LOH was intraoperative triamcinolone use (P < 0.001). Secondary predictors were a preoperative intraocular pressure more than 15 mmHg (P < 0.001) in eyes that use triamcinolone, and postvitrectomy pseudophakic/aphakic status (P = 0.007) in eyes that did not use triamcinolone. Conclusion: Late-onset ocular hypertension occurred in 4.9% of vitrectomized eyes. The main risk factors were intraoperative use of triamcinolone and postvitrectomy pseudophakic/aphakic status.
Original languageEnglish
Pages (from-to)2107-2115
Number of pages9
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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