L’aldosterone plasmatico e la sua relazione con la massaventricolare sinistra nei pazienti ipertesi con malattia renalecronica I-III stadio NKF

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[automatically translated] RATIONAL. Chronic kidney disease (CKD) is associated with un'incrementata left ventricular mass (LVM), which may predispose to an increased risk of cardiovascular events. The plasma concentrations of aldosterone (PAC) are often increased in advanced stages of CKD. Little is known about the levels of aldosterone and their relationship with LVM in patients with mild CKD-moderataL'obiettivo of our study we were to analyze the CAP and LVM and their relationship in a group of hypertensive patients with CKD stages to I- III National Kidney Foundation (NKF). CASES AND METHODS. We enrolled 195 hypertensive patients with CKD stages I to III-NKF and we compared them to a control group, consisting of 82 hypertensive patients without renal dysfunction, homogeneous for age and sex. Patients, in the wash-out by anti-hypertensive drugs, underwent dosage of plasma renin activity and aldosterone, blood pressure monitoring 24 hours and echocardiogram. RESULTS. LVM was higher in patients with CKD than in controls and progressively increased with advancing stages of CKD (ANOVA: p = 0.004). We observed a similar trend for the CAP (ANOVA: p <0.0001). Furthermore, we found a highly significant direct correlation between CAP and LVM in patients with CKD (r = 0:29; p <0.0001). This association remained significant multiple regression analysis after adjustment for various confounding factors (p <0.0001). CONCLUSIONS. Our results show that, in hypertensive patients with CKD, LVM and PAC may be fostered and interconnected, since the early stages of kidney dysfunction. It seems biologically plausible to speculate that aldosterone may contribute to increased LVM in hypertensive patients with early CKD. The
Original languageItalian
Number of pages1
Publication statusPublished - 2014

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